N-ACETYL-S-[(2R,3S,4R)-3-HYDROXY-2-[(1S)-1-HYDROXY-2-METHYLPROPYL]-4-METHYL-5-OXO-2-PYRROLIDINECARBONYL]-L-CYSTEINE
蛋白酶体抑制剂(LACTACYSTIN)
CAS: 133343-34-7
化学式: C15H24N2O7S
| 中文名 | 蛋白酶体抑制剂 |
| 英文名 | LACTACYSTIN |
| 别名 | 乳胞素 蛋白酶体抑制剂 蛋白酶体抑制剂 5级 |
| 英文别名 | LACTACYSTIN (+)-LACTACYSTIN LACTACYSTIN (NATIVE) LACTACYSTIN, SYNTHETIC LACTACYSTIN, STREPTOMYCES SP 3S-HYDROXY-2R-(1-HYDROXY-2-METHYLPROPYL)-4R-METHYL-5-OXO-2-PYRROLIDINECARBOXYLATE-N-ACETYL-L-CYSTEINE N-ACETYL-S-[(2R,3S,4R)-3-HYDROXY-2-[(1S)-1-HYDROXY-2-METHYLPROPYL]-4-METHYL-5-OXO-2-PYRROLIDINECARBONYL]-L-CYSTEINE (2R,3S,4R)-3-HYDROXY-2-[(1S)-1-HYDROXY-2-METHYLPROPYL]-4-METHYL-5-OXO-2-PYRROLIDINECARBOXY-N-ACETYL-L-CYSTEINE THIOESTER |
| CAS | 133343-34-7 |
| EINECS | 200-258-5 |
| 化学式 | C15H24N2O7S |
| 分子量 | 376.43 |
| 密度 | 1.367±0.06 g/cm3(Predicted) |
| 熔点 | 233-235°C dec. |
| 沸点 | 714.9±60.0 °C(Predicted) |
| 溶解度 | 溶于DMSO (高达20 mg/ml)，水 (高达10 mg/ml) 或乙醇 (高达1 mg/ml)。 |
| 酸度系数 | 3.11±0.10(Predicted) |
| 存储条件 | -20°C |
| 稳定性 | 从提供的购买之日起稳定2年。在DMSO或乙醇中的溶液可以在-20 ° 储存长达1个月。水溶液不稳定，必须在一个工作日内使用。 |
| 外观 | 粉末 |
| 颜色 | White to off-white |
| 体内研究 | Lactacystin (microinjection; 2 µg) induces a Parkinson’s disease-like motor phenotype 5-7 days after injection in young and adult mice. Animal Model: Male C57Bl/6RccHsd mice with 8-9 weeks (young) and 12-14 months (adult) old Dosage: 2 µg Administration: Microinjection Result: Induced a Parkinson’s disease-like motor phenotype 5-7 days after injection in young and adult mice. |
| WGK Germany | 3 |
| 参考资料 展开查看 | 1. [IF=10.392] Haoran Wei et al."KDELR2 promotes breast cancer proliferation via HDAC3-mediated cell cycle progression."Cancer Commun. 2021 Sep;41(9):904-920 |
![N-ACETYL-S-[(2R,3S,4R)-3-HYDROXY-2-[(1S)-1-HYDROXY-2-METHYLPROPYL]-4-METHYL-5-OXO-2-PYRROLIDINECARBONYL]-L-CYSTEINE](http://res.chembk.com/assets/images/structure/133343-34-7.gif)
供应商列表
现货供应
产品名: Lactacystin 去供应商网站查看 询盘CAS: 133343-34-7
产地: 美国
包装: 50 μg;100 μg
规格: HY-16594
库存: 现货，货期：1-2天
电话: 021-38924433; 021-58955995
手机: 18019480960
电子邮件: sales@medchemexpress.cn
产品描述: 产品覆盖：8万多种抑制剂，11000+靶点蛋白，数百款试剂盒，200+生物活性化合物库，天然产物，抗体等. 纯度: 98.20%
现货供应
产品名: Lactacystin 去供应商网站查看 询盘CAS: 133343-34-7
产地: 美国
包装: 50 μg;100 μg
规格: HY-16594
库存: 现货，货期：1-2天
电话: 021-38924433; 021-58955995
手机: 18019480960
电子邮件: sales@medchemexpress.cn
产品描述: 产品覆盖：8万多种抑制剂，11000+靶点蛋白，数百款试剂盒，200+生物活性化合物库，天然产物，抗体等. 纯度: 98.20%
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N-ACETYL-S-[(2R,3S,4R)-3-HYDROXY-2-[(1S)-1-HYDROXY-2-METHYLPROPYL]-4-METHYL-5-OXO-2-PYRROLIDINECARBONYL]-L-CYSTEINE Phosphorothioic acid, O,O-diethyl ester, O-ester with p-hydroxybenzaldehyde O-[[2-(diethylamino)ethyl]carbamoyl]oxime (8CI) 5-CHLORO-2-METHYL-4-(TRIFLUOROMETHYL)PHENYLBORONIC ACID, PINACOL ESTER 6-[(4'-{[4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]amino}[1,1'-biphenyl]-4-yl)amino]-2-(hydroxymethyl)tetrahydro-2H-pyran-3,4-diol (1S)-1-[3-FLUORO-4-(TRIFLUOROMETHOXY)PHENYL]-2-METHOXYETHYLAMINE HYDROCHLORIDE 2-Dimethylaminoisopropyl chloride hydrochloride 16-Hydroxy-8(17),13-labdadien-1 Pomalidomide 4'-PEG2-azide Haloperidol Octanoate 4-氯-2,6-二苯基苯并[H]喹啉
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